The Significance of Donor-Specific HLA Antibodies in Rejection and Ductopenia Development in ABO Compatible Liver Transplantation.
Musat AI, Agni RM, Wai PY, Pirsch JD, Lorentzen DF, Powell A, Leverson GE, Bellingham JM, Fernandez LA, Foley DP, Mezrich JD, D'Alessandro AM, Lucey MR. Am J Transplant. 2011 Mar;11(3):500-10. (CUMC Full Text PDF)
This is the latest addition to a rapidly increasing number of articles showing a possible important role for humoral rejection in cases of liver allograft rejection. Applying the currently used strategy for detection of antibody-mediated rejection in other solid organs (using C4d staining and presence of donor-specific HLA antibodies), the authors conclude that humoral alloreactivity is frequently present in cases of "cellular" rejection in ABO-compatible liver allografts.
Musat AI, Agni RM, Wai PY, Pirsch JD, Lorentzen DF, Powell A, Leverson GE, Bellingham JM, Fernandez LA, Foley DP, Mezrich JD, D'Alessandro AM, Lucey MR. Am J Transplant. 2011 Mar;11(3):500-10. (CUMC Full Text PDF)
This is the latest addition to a rapidly increasing number of articles showing a possible important role for humoral rejection in cases of liver allograft rejection. Applying the currently used strategy for detection of antibody-mediated rejection in other solid organs (using C4d staining and presence of donor-specific HLA antibodies), the authors conclude that humoral alloreactivity is frequently present in cases of "cellular" rejection in ABO-compatible liver allografts.
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