Constitutional telomerase mutations are genetic risk factors for cirrhosis.
Calado RT, Brudno J, Mehta P, Kovacs JJ, Wu C, Zago MA, Chanock SJ, Boyer TD, Young NS. Hepatology. 2011 May;53(5):1600-7. (CUMC Full Text PDF).
Telomerase gene mutations are associated with cirrhosis formation.
Hartmann D, Srivastava U, Thaler M, Kleinhans KN, N'kontchou G, Scheffold A, Bauer K, Kratzer RF, Kloos N, Katz SF, Song Z, Begus-Nahrmann Y, Kleger A, von Figura G, Strnad P, Lechel A, Günes C, Potthoff A, Deterding K, Wedemeyer H, Ju Z, Song G, Xiao F, Gillen S, Schrezenmeier H, Mertens T, Ziol M, Friess H, Jarek M, Manns MP, Beaugrand M, Rudolph KL. Hepatology. 2011 May;53(5):1608-17. (CUMC Full Text PDF).
These two remarkably similar publications in this month's issue of Hepatology investigate the role of telomerase mutations as potential risk factors for development of cirrhosis in the setting of chronic liver disease of various types.
Calado RT, Brudno J, Mehta P, Kovacs JJ, Wu C, Zago MA, Chanock SJ, Boyer TD, Young NS. Hepatology. 2011 May;53(5):1600-7. (CUMC Full Text PDF).
Telomerase gene mutations are associated with cirrhosis formation.
Hartmann D, Srivastava U, Thaler M, Kleinhans KN, N'kontchou G, Scheffold A, Bauer K, Kratzer RF, Kloos N, Katz SF, Song Z, Begus-Nahrmann Y, Kleger A, von Figura G, Strnad P, Lechel A, Günes C, Potthoff A, Deterding K, Wedemeyer H, Ju Z, Song G, Xiao F, Gillen S, Schrezenmeier H, Mertens T, Ziol M, Friess H, Jarek M, Manns MP, Beaugrand M, Rudolph KL. Hepatology. 2011 May;53(5):1608-17. (CUMC Full Text PDF).
These two remarkably similar publications in this month's issue of Hepatology investigate the role of telomerase mutations as potential risk factors for development of cirrhosis in the setting of chronic liver disease of various types.
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