Diagnostic accuracy of clathrin heavy chain staining in a marker panel for the diagnosis of small hepatocellular carcinoma.
Di Tommaso L, Destro A, Fabbris V, Spagnuolo G, Laura Fracanzani A, Fargion S, Maggioni M, Patriarca C, Maria Macchi R, Quagliuolo M, Borzio M, Iavarone M, Sangiovanni A, Colombo M, Roncalli M. Hepatology. 2011 May;53(5):1549-57. (CUMC Full Text PDF). (also see editorial [CUMC Full Text]).
Di Tommaso et al investigate the contribution of clathrin heavy chain (in addition to glypican-3, glutamine synthetase, and heat-shock protein 70) in the diagnosis of HCC on needly biopsy. The addition of CHC to the panel increased the diagnostic accuracy for small HCCs from 76.9% to 84.3%, and there was an increase in sensitivity from 46.8% to 63.8%.
Di Tommaso L, Destro A, Fabbris V, Spagnuolo G, Laura Fracanzani A, Fargion S, Maggioni M, Patriarca C, Maria Macchi R, Quagliuolo M, Borzio M, Iavarone M, Sangiovanni A, Colombo M, Roncalli M. Hepatology. 2011 May;53(5):1549-57. (CUMC Full Text PDF). (also see editorial [CUMC Full Text]).
Di Tommaso et al investigate the contribution of clathrin heavy chain (in addition to glypican-3, glutamine synthetase, and heat-shock protein 70) in the diagnosis of HCC on needly biopsy. The addition of CHC to the panel increased the diagnostic accuracy for small HCCs from 76.9% to 84.3%, and there was an increase in sensitivity from 46.8% to 63.8%.
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