Noninvasive diagnosis of acute cellular rejection in liver transplant recipients: A proteomic signature validated by enzyme-linked immunosorbent assay.
Massoud O, Heimbach J, Viker K, Krishnan A, Poterucha J, Sanchez W, Watt K, Wiesner R, Charlton M. Liver Transpl. 2011 Jun;17(6):723-32. (CUMC Full Text).
A serum proteome signature was identified in a group of patients with histology-proven ACR. Differentially expressed proteins included serum amyloid A, complement component 4 (C4), fibrinogen, complement component 1q (C1q), complement component 3, heat shock protein 60 (HSP60), and HSP70. Immunohistochemical markers for several of these proteins are available and it would be interesting if tissue samples would also reflect the increased expression of these proteins observed in serum in this study.
Massoud O, Heimbach J, Viker K, Krishnan A, Poterucha J, Sanchez W, Watt K, Wiesner R, Charlton M. Liver Transpl. 2011 Jun;17(6):723-32. (CUMC Full Text).
A serum proteome signature was identified in a group of patients with histology-proven ACR. Differentially expressed proteins included serum amyloid A, complement component 4 (C4), fibrinogen, complement component 1q (C1q), complement component 3, heat shock protein 60 (HSP60), and HSP70. Immunohistochemical markers for several of these proteins are available and it would be interesting if tissue samples would also reflect the increased expression of these proteins observed in serum in this study.
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