Advanced histology and impaired liver regeneration are associated with disease severity in acute-onset autoimmune hepatitis.
Fujiwara K, Nakano M, Yasui S, Okitsu K, Yonemitsu Y, Yokosuka O. Histopathology. 2011 Apr;58(5):693-704. (CUMC Full Text PDF).
Semiquantitative evaluation of ductular reaction, intermediate hepatocytes and hepatic progenitor cells, as assessed by cytokeratin 7 immunostaining was used by the authors to study patients presenting with autoimmune hepatitis of different severities. The authors conclude that the above features reflect impaired liver regeneration and may represent useful prognostic markers in this setting. It would have been interesting if the authors had also studied the expression of p21, a known marker of replicative arrest, in these patients.
Fujiwara K, Nakano M, Yasui S, Okitsu K, Yonemitsu Y, Yokosuka O. Histopathology. 2011 Apr;58(5):693-704. (CUMC Full Text PDF).
Semiquantitative evaluation of ductular reaction, intermediate hepatocytes and hepatic progenitor cells, as assessed by cytokeratin 7 immunostaining was used by the authors to study patients presenting with autoimmune hepatitis of different severities. The authors conclude that the above features reflect impaired liver regeneration and may represent useful prognostic markers in this setting. It would have been interesting if the authors had also studied the expression of p21, a known marker of replicative arrest, in these patients.
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