Claudins and tricellulin in fibrolamellar hepatocellular carcinoma.
Patonai A, Erdélyi-Belle B, Korompay A, Somorácz A, Straub BK, Schirmacher P, Kovalszky I, Lotz G, Kiss A, Schaff Z. Virchows Arch. 2011 Apr 19. [Epub ahead of print]. (CUMC Full Text PDF).
The histogenesis of fibrolamellar HCC has long been debated. With emerging evidence for 'stem cell' carcinomas and tumors with divergent/bilineal differentiation, some of the morphologic, immunohistochemical, and molecular features of FL-HCC have been re-examined in this context. The authors of this study detected a claudin expression pattern in FL-HCC that is more similar to conventional HCC's than to cholangiocarcinomas. However, tight junction protein expression is qualitatively and quantitatively different from both conventional HCCs and cholangiocarcinomas.
Patonai A, Erdélyi-Belle B, Korompay A, Somorácz A, Straub BK, Schirmacher P, Kovalszky I, Lotz G, Kiss A, Schaff Z. Virchows Arch. 2011 Apr 19. [Epub ahead of print]. (CUMC Full Text PDF).
The histogenesis of fibrolamellar HCC has long been debated. With emerging evidence for 'stem cell' carcinomas and tumors with divergent/bilineal differentiation, some of the morphologic, immunohistochemical, and molecular features of FL-HCC have been re-examined in this context. The authors of this study detected a claudin expression pattern in FL-HCC that is more similar to conventional HCC's than to cholangiocarcinomas. However, tight junction protein expression is qualitatively and quantitatively different from both conventional HCCs and cholangiocarcinomas.
No comments:
Post a Comment